Dr hab. inż. Artur Cieślar-Pobuda, Współpracownik
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Computer Hope




Nota biograficzna:

2012 - adiunkt w Instytucie Automatyki Politechniki Śląskiej,

Zainteresowania naukowe:

•Biotechnologia

•Inżynieria biomedyczna

Lista publikacji:

1. Skonieczna M, Cieslar-Pobuda A, Saenko Y, Foksinski M, Olinski R, Rzeszowska-Wolny J et al. The impact of DIDS-induced inhibition of voltage-dependent anion channels (VDAC) on cellular response of lymphoblastoid cells to ionizing radiation. Med Chem 2017, 13(5):477-483, doi: 10.2174/15734064z13666170421102353

2. Sherrell PC, Cieslar-Pobuda A, Ejneby MS, Sammalisto L, Gelmi A, de Muinck E et al. Rational Design of a Conductive Collagen Heart Patch. Macromol Biosci 2017, 17(7):1600446, 10 pages, doi: 10.1002/mabi.201600446

3. Cieslar-Pobuda A, Knoflach V, Ringh MV, Stark J, Likus W, Siemianowicz K et al. Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences. Biochim Biophys Acta 2017, 1864(7):1359-1369, https://doi.org/10.1016/j.bbamcr.2017.04.017

4. M. Skonieczna, T. Hejmo, A.Poterala-Hejmo, A. Cieslar-Pobuda, R. J. Buldak, NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells, Oxid.Med. Cell. Long. 2017 (2017):9420539, https://doi.org/10.1155/2017/9420539

5. A Cieślar-Pobuda, J Yue, HC Lee, M Skonieczna, YH Wei, ROS and Oxidative Stress in Stem Cells, Oxidative Medicine and Cellular Longevity, Volume 2017 (2017), Article ID 5047168, 2 pages, https://doi.org/10.1155/2017/5047168

6. W. Likus, K. Siemianowicz, K. Bieńk, M. Pakuła, H. Pathak, C. Dutta, Q. Wang, S. Shojaei, Y. G. Assaraf, S. Ghavami, A. Cieślar-Pobuda, M. J. Łos; Could drugs inhibiting the mevalonate pathway also target cancer stem cells? Drug Resistance Updates, 2016, 25(3):13-25, dx.doi.org/10.1016/j.drup.2016.02.001

7. Jain MV, Shareef A, Likus W, Cieslar-Pobuda A, Ghavami S, Los MJ, Inhibition of miR301 enhances Akt-mediated cell proliferation by accumulation of PTEN in nucleus and its effects on cell-cycle regulatory proteins. Oncotarget 2016; 7(15):20953-65. doi:10.18632/oncotarget.7996

8. Akbari-Birgani S, Paranjothy T, Zuse A, Janikowski T, Cieslar-Pobuda A, Likus W, et al. Cancer stem cells, cancer-initiating cells and methods for their detection. Drug Discov Today. 2016; 21(5):836-42. doi:10.1016/j.drudis.2016.03.004

9. Gelmi A, Cieslar-Pobuda A, de Muinck E, Los M, Rafat M and Jager EW. Direct Mechanical Stimulation of Stem Cells: A Beating Electromechanically Active Scaffold for Cardiac Tissue Engineering. Adv Healthc Mater. 2016 Jun;5(12):1471-80. doi: 10.1002/adhm.201600307

10. A. Cieślar-Pobuda, M. Rafat, V. Knoflach, M., Skonieczna, A. Hudecki, A. Małecki, E. Urasińska, S. Ghavami, M. J. Łos, Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells, Oncotarget, 2016, 7(27):42314-42329, DOI: 10.18632/oncotarget.9791

11. P. C.Sherrell, K. Elmen, A. Cieslar-Pobuda, E. Wiechec, M. Lemoine, Z. Arzhangi, M. Silvera-Ejneby, J. Brask, J. N.Daka, M. Rafat, Cardiac and Stem Cell-Cocooned Hybrid Microspheres: A Multi Factorial Design Approach, Sensors and Actuators B: Chemical, 2016, 236:480–489, http://dx.doi.org/10.1016/j.snb.2016.06.002

12. Stodolak-Zych E, Mandera K, Likus W, Los M and Cieslar-Pobuda A. Nanocomposite membrane modified by different carbon nanoforms as potential materials for peripheral nerves implants, 2016. 10th World Biomaterials Congress (WBC), 17/05/2016-22/05/2016, Montreal, Kanada. Frontiers in Bioengineering and Biotechnology, pp. 1, DOI: 10.1109/MMAR.2017.8046940

13. K. Magnusson, H. Appelqvist, A. Cieślar-Pobuda, J. Wigenius, T. Karlsson, MJ. Łos, B. Kågedal, J. Jonasson and KPR Nilsson. Differential vital staining of normal fibroblasts and melanoma cells by an anionic conjugated polyelectrolyte. Cytometry Part A. 2015 Mar;87(3):262-72. doi: 10.1002/cyto.a.22627. Epub 2015 Jan 20.

14. T. Bose, A. Cieślar-Pobuda, E. Wiechec, Role of ion channels in regulating Ca2+ homeostasis during the interplay between immune and cancer cells, Cell death & disease, 6 (2015) e1648. doi:10.1038/cddis.2015.23

15. M.V. Jain, J.R. Jamgamreddy, J. Grabarek, F. Schweizer, T. Klonisch, A. Cieslar-Pobuda, M.J. Los, Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21 and p27, Cell Cycle, 2015; 14(13):2109-20. doi: 10.1080/15384101.2015.1041692

16. R. Shakeri, S. Hosseinkhani, M.J. Los, J. Davoodi, M.V. Jain, A.Cieslar-Pobuda, M. Rafat, S.K. Ardestani, Role of the salt bridge between glutamate 546 and arginine 907 in preservation of autoinhibited form of Apaf-1, International journal of biological macromolecules, 2015 Aug 13. pii: S0141-8130(15)00562-0. doi: 10.1016/j.ijbiomac.2015.08.027

17. A. Cieślar-Pobuda, M.V. Jain, G. Kratz, J. Rzeszowska-Wolny, S. Ghavami, E. Wiechec, The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells, Oncotarget, 2015 Oct 6;6(30):29753-70. doi: 10.18632/oncotarget.4995

18. P Nilsson, KE Magnusson, H Appelqvist, A Cieslar-Pobuda, M Bäck; An imidazole functionalized pentameric thiophene displays different staining patterns in normal and malignant cells,
Frontiers in Chemistry 3: 58, 2015, doi: 10.3389/fchem.2015.00058

19. A. Gelmi, J. Zhang, A. Cieslar-Pobuda ,et.al. Electroactive 3D Materials for Cardiac Tissue Engineering, Proc. of SPIE Vol. 9430, Electroactive Polymer Actuators and Devices EAPAD 2015, April 1, 2015; doi:10.1117/12.2084165

20. Mehrdad Rafat, Peter C. Sherrell, Laura Sammalisto, Artur Cieslar-Pobuda, Malin Silverå Ejneby, Johan. Brask, Marek J. Los, Rational Development of a Bioengineered Carbon Nanotube-Reinforced Cardiac Patch,
Advanced Materials World Congress, Stockholm, Sweden 2015

21. A. Cieślar-Pobuda, M. V. Jain, G. Kratz, J. Rzeszowska-Wolny, S. Ghavami, E. Wiecheć, PFKFB3-expression Pattern Distinguishes Between Induced-Pluripotent Stem Cells and Cancer-Stem Cells, 27th European Conference on Biomaterials, Krakow, Poland, 30th August – 3rd September 2015

22. A. Cieślar-Pobuda, V. Knoflach, S. Ghavami, M. Łos, Generation of Limbal Epithelial Cell Progenitors by Two Methods: by Differentiation form iPS Cells and by Direct Trans-differentiation form Human Dermal Fibroblasts, 27th European Conference on Biomaterials, Krakow, Poland, 30th August – 3rd September 2015

23. A. Cieslar-Pobuda, V. Knoflach, M. Skonieczna, K.Gajda, E.Wiechec, M.Los; Human induced pluripotent stem cell differentiation and direct transdifferentiation into corneal epithelial-like cells, 6th EMBO Meeting, 5-8 September, 2015, Birmingham, United Kingdom

24. A. Cieślar-Pobuda , K. Magnusson, H. Appelqvist, B. Kagedal, J. Jonasson, K. P. R. Nilsson, M. J. Łos Novel Oligo-Thiophene-based dyes, new promising tool for identification of cell subpopulations, XLIX Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików, Międzyzdroje, Poland, 09-12 September 2015

25. A. Cieślar-Pobuda, M. V. Jain, G. Kratz, J. Rzeszowska-Wolny, S. Ghavami, E. Wiecheć, Poziom ekspresji PFKFB3, głównego enzymu uczestniczącego w glikolizie rozróżnia indukowane pluripotencjalne komórki macierzyste od komórek macierzystych raka, XLIX Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików, Międzyzdroje, Poland, 09-12 September 2015

26. Wasik AM. Grabarek J. Pantovic A. Cieślar-Pobuda A. Asgari HR. Bundgaard-Nielsen C. Rafat M. Dixon IM. Ghavami S. Los MJ: Reprogramming and carcinogenesis-parallels and distinctions. International Review of Cell and Molecular Biology 2014 308:167-203.

27. Cieślar-Pobuda A. Bäck M. Magnusson K. Jain MV. Rafat M. Ghavami S. Nilsson KP. Los MJ: Cell type related differences in staining with pentameric thiophene derivatives. Cytometry A. 2014 85(7):628-35 doi: 10.1002/cyto.a.22437.

28. R. Jaksik, A. Lalik, M. Skonieczna, A. Cieslar-Pobuda, S. Student, J. Rzeszowska-Wolny,MicroRNAs and reactive oxygen species: Are they in the same regulatory circuit?, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 764–765 (2014), 64–71

29. A. Cieslar-Pobuda, E. Wiechec, Research on liver regeneration as an answer to the shortage of donors for liver transplantation, Hepatol Res, 44 (2014) 944-946.

30. W. Chaabane, A. Cieslar-Pobuda, M. El-Gazzah, M.V. Jain, J. Rzeszowska-Wolny, M. Rafat, J. Stetefeld, S. Ghavami, M.J. Los, Human-Gyrovirus-Apoptin Triggers Mitochondrial Death Pathway-Nur77 is Required for Apoptosis Triggering, Neoplasia, 16 (2014) 679-693

31. Cieslar-Pobuda, S. Ghavami, E. Wiechec-Los, Cell cycle regulation in cancer stem cells and iPS cells- the role of PFKFB3,17th International Symposium on Molecular Medicine, At Athens, Greece, Volume: Int J Mol Med, 34 (2014) S107-S107

32. M.Rafat, K. Elmén, P. Sherrill, A. Cieślar-Pobuda, E. Wiechec, M. J. Los, B. Liedberg: Multifactorial Optimization of Cell-Cocooned Collagen-Alginate Microspheres for Cardiac Tissue Engineering. 3rd International Conference on Tissue Science & Regenerative Medicine, September 24-26, 2014 Valencia, Spain

33. K. Magnusson, H. Appelqvist, A. Cieślar-Pobuda, M. J. Łos, B. Kågedal, J. Jonasson, K. P. R. Nilsson: The use of thiophene probes to discriminate normal cells from transformed cells. 24th Anniversary World Congress on Biosensors ,27-30 May 2014, Melbourne, Australia

34. Cieślar-Pobuda A. Los MJ: Prospects and limitations of Click-Chemistry-based DNA labeling technique employing 5-ethynyl-2'deoxyuridine (EdU). Cytometry A. 2013 Nov.83(11):977-8

35. Jangamreddy JR. Ghavami S. Grabarek J. Kratz G. Wiechec E. Fredriksson BA. Rao Pariti RK. Cieślar-Pobuda A. Panigrahi S. Łos MJ: Salinomycin induces activation of autophagy. mitophagy and affects mitochondrial polarity: differences between primary and cancer cells. Biochim Biophys Acta. 2013 Sep.1833(9):2057-69. doi: 10.1016/j.bbamcr.2013.04.011.

36. Y. Saenko, A. Cieslar-Pobuda, M. Skonieczna, J. Rzeszowska-Wolny, Changes of reactive oxygen and nitrogen species and mitochondrial functioning in human K562 and HL60 cells exposed to ionizing radiation. Radiation Research, 2013, 180(4), 360-366.

37. Gajda K, Skonieczna M, Cieslar-Pobuda A, Saenko Y, Rzeszowska-Wolny J, Induction of reactive oxygen and nitrogen species at different stages of the cell cycle and after exposure of human K562 and HL60 cells to ionizing radiation. Febs Journal 280: 244-244. (38th Congress of the Federation-of-European-Biochemical-Societies (FEBS), Saint Petersburg, RUSSIA Date: JUL 06-11, 2013)

38. Los MJ, Jangamreddy JR, Ghavami S, Cieslar-Pobuda A: Salinomycin – experimental drug with preferred toxicity towards cancer stem cells, the role of autophagy in salinomycin toxicity. XVII Gliwice Scientific Meetings, Book of abstracts, p.46. 15-16.11.2013, Gliwice, Poland

39. M. Widel, W.M. Przybyszewski, A. Cieslar-Pobuda, Y.V. Saenko, J. Rzeszowska-Wolny,Bystander normal human fibroblasts reduce damage response in radiation targeted cancer cells through intercellular ROS level modulation, Mutat Res, 731 (2012) 117-124

40. A. Cieslar-Pobuda, Y. Saenko, J. Rzeszowska-Wolny, PARP-1 inhibition induces a late increase in the level of reactive oxygen species in cells after ionizing radiation, Mutat Res, 732 (2012) 9-15.

41. Rzeszowska-Wolny J, Widel M, Cieslar-Pobuda A, Lalik A, Skonieczna M, et al. Reactive Oxygen Species May Play a Role in Ionizing Radiation-induced Bystander Effects and Regulation of mRNA Levels by MicroRNAs. European Journal of Cancer 48: S271-S272. ( 22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN Date: JUL 07-10, 2012)

42. Cieslar-Pobuda A, Saenko Y, Skonieczna M, Rzeszowska-Wolny J., Increased Levels of Reactive Oxygen and Nitrogen Species in Cells Exposed to Ionizing Radiation. European Journal of Cancer 48: S271-S271. (22nd Biennial Congress of the European-Association-for-Cancer-Research, Barcelona, SPAIN Date: JUL 07-10, 2012)

43. Skonieczna M., Cieślar-Pobuda A., Student S., Bednorz R., Wideł M., Rzeszowska-Wolny J.: Dose dependent oxidative stress and nuclear damage In the HCT116 and Raji cancer cells following ionizing radiation exposure, Gliwice Scientific Meetings, Abstracts, 2010, p 93.

44. Skonieczna M., Student S., Cieślar-Pobuda A., Rzeszowska-Wolny J., Studies of the oxidative stress induced by ionizing radiation in cancer cells, V Konferencja: Analityczne Zastosowania Chromatografii Cieczowej, Warszawa 2010, p. 25, ISBN 83-89379-08-1

45. Skonieczna M, Student S, Cieślar-Pobuda A, Herok R, Jaksik R, Rzeszowska-Wolny J:“Oxidative RNA damage and its potential role in cellular responses to radiation” Acta Biochmica Polonica, Abstracts of the 45th Meeting of the Polish Biochemical Society, 20-23th September 2010, Wisła, Poland, p. 131

46. N.I. Ryabokon, A. Cieslar-Pobuda, J. Rzeszowska-Wolny, Inhibition of poly(ADP-ribose) polymerase activity affects its subcellular localization and DNA strand break rejoining, Acta Biochim Pol, 56 (2009) 243-248.

47. Skonieczna M., Cieślar-Pobuda A., Student S., Rzeszowska-Wolny J. ”Effects of an oxidative stress on human K562 and ME45 cancer cells” The Wilhelm Bernhard Workshop 21st International Workshop on the Cell Nucleus, Ustroń, Poland, 31 August – 4 September 2009

48. Cieślar-Pobuda A., Skonieczna M., Student S., Lalik A., Rzeszowska-Wolny J.,“Oxidative damage and DNA repair in human cancer cells” Acta Biochim. Polonica , Abstracts of the 44th Meeting of the Polish Biochemical Society (Suppl.3), p.80, 2009

49. M. Skonieczna, A.Lalik, A.Cieślar-Pobuda, S.Student, J.Rzeszowska-Wolny: “Insights into DNA repair system In colon cancer cell lines exposed to ionizing radiation. Gliwice Scientific Meetings 2008, streszczenia str. 66

50. Ryabakon N. Rzeszowska-Wolny J., Cieślar-Pobuda A :„Poly(ADP-ribose) foci in cancer cells induced by ionised radiaton”, II Ogólnopolskie Spotkania Użytkowników Mikroskopów Konfokalnych, Poznań 28 – 30 maja 2008

51. Student S., Cieślar-Pobuda A., M. Skonieczna, A.Lalik, R. Herok, K.Pietranek, M.Wideł, J.Rzeszowska-Wolny “DNA repair in cells differing in p53 status” Acta Biochmica Polonica, Supp. 3, Abstracts of the 43rd Meeting of the Polish Biochemical Society and 10th Conference of Polish Cell Biology Society, 7 – 11st September 2008, Olsztyn, Poland

52. J. Rzeszowska-Wolny, A. Cieślar-Pobuda, N. Ryabokon, “Modulation of poly (ADP-ribose) synthesis and the kinetics of DNA strand rejoining”, EMBO Conference Series on Nuclear Structure and Dynamics. Montpellier, France, 1-5 September 2007

53. A. Cieślar-Pobuda, J.Rzeszowska-Wolny, “Ionizing radiation induced synthesis of poly(ADP-ribose) correlates with the amount of cellular DNA but the speed of synthesis and decomposition is not cell cycle dependent”, International Workshop on Ionic Channels, Szczyrk, 27 May -1 June 2007

54. A. Cieślar-Pobuda, K. Pawełek “Nerve Membranes- FitzHugh-Nagumo Model”, 18th Marian Smoluchowski Symposium on Statistical Physics, Zakopane, Poland, September 3-6, 2005